' AgeCare - Academy of Geriatric Cancer Research

Aim and idea of the Centre                                                                     

In 2010, 35,563 persons were diagnosed with cancer in Denmark of whom 45% of men and 41% of women were aged 70+ years. This proportion will increase markedly over the next years, primarily because of the aging population. Our knowledge of elderly cancer patients’ tolerance to and benefit from antineoplastic treatment is sparse due to underrepresentation of this patient group in clinical trials. In the period from 2007 to June 2010, 24 drugs were approved by FDA for the treatment of cancer, and only 33% of patients included in the registration trials were age 65 years or older compared to 59% of the US cancer population aged 65 years or older [1]. It is unethical to suggest evidence-based antineoplastic therapy based on chronologic age alone. Because clinical trials primarily include younger more fit patients, such results may not be applicable to the elderly without additional risk assessment. Elderly patients often suffer from reduced organ function (kidney, liver, bone marrow) and one or more comorbid conditions, factors that can impair the tolerability of antineoplastic treatment. In addition some have cognitive dysfunctions resulting in difficulties in complying with the recommended treatment. At the time of diagnosis, the mean number of drugs used by 70+ year-old Danish cancer patients is 4,6, a number that increases when antineoplastic therapy is initiated and supportive care drugs are needed as well. This constitutes a high risk of adverse effects due to drug-drug interactions.   
Internationally, there is a rapidly growing appreciation of the need for specific strategies in the management of elderly cancer patients. The International Society of Geriatric Oncology (SIOG) was founded in 2000 and the Journal of Geriatric Oncology in 2010. SIOG has recently (2011) defined the 10 most important initiatives in geriatric oncology. In addition to education and clinical practice, four of these initiatives are related to research. In the US, the Cancer and Aging Research Group (www.mycarg.org), the National Cancer Institute (www.cancer.gov) and the National Institute on Aging (www.nia.nih.gov) have planned three conferences (from 2010-2015), to identify the knowledge gaps in geriatric oncology and to propose research methods and strategies to fill these gaps. The conclusions of the first conference were published in March 2012 [2] and emphasized that future oncology research in older adults should focus on 1) improved standardized geriatric assessments, 2) substantially enhanced biological assessments, 3) specific trials for the elderly and most vulnerable patients, and 4) research infrastructure specifically targeting older adults and substantially strengthened geriatrics and oncology research collaborations. In the UK, a recent report concluded that there is a strong need for specific assessment methods and identification and management of comorbidity in older cancer patients. Consequently the Macmillan Cancer Support, Age UK and the Department of Health have initiated 5 pilot projects testing new methods for assessment of older people with cancer [3].

In Denmark, there is no national strategy for the management of elderly cancer patients, and current treatment decisions are primarily based on chronologic age and insufficient evaluations of functional levels, such as scoring of ECOG performance status. In addition, since we are currently unable to accurately predict the efficacy of antineoplastic therapy in the elderly, some will not receive treatment while others will be offered treatment despite the potential lack of any benefit. The failure to address the need for a national strategy could have a fundamental impact on the sustainability of the health care system.

At Odense University Hospital, all cancer patients are evaluated by multidisciplinary teams (MDT) including not only the different specialties involved in the clinical management of cancer patients but also a multidisciplinary research organization encompassing all aspects from molecular and genetic science to the clinical palliation of terminal cancer patients.

Patient selection and individually tailored treatment strategies are potential key points in improving survival and minimizing toxicity of treatment, especially in elderly patients. To accomplish this, we need specific and individual mapping regarding details of several disease characteristics in each patient. Ideally, this mapping should cover identification of pre-therapeutic molecular biomarkers and their prognostic and predictive value. In combination with detailed staging at diagnosis and evaluation of clinical baseline characteristics, this multidisciplinary approach will allow a treatment plan tailored to each patient. 

Translational research is an important new area in cancer research giving insight into molecular mechanisms underlying clinical conditions. The field of cancer in the elderly has only been slightly addressed by translational researchers, although it seems evident that the biology of cancer cells and the surrounding normal cells in the elderly is significantly altered. These factors need to be further investigated and might become important in future treatment strategies for elderly cancer patients.

The proposed research centre acknowledges that the time has come for oncologists, geriatricians, surgeons and other related health care professionals as well as translational scientists to work together to focus on individualized management of older cancer patients to improve treatment and care


Aim of AgeCare
To optimize cancer therapy and supportive care in older cancer patients.


Scientific Content of AgeCare

  • Epidemiological and biodemographic research in elderly focusing cancer and aging.Biological assessment of older patients including pharmacokinetics and pharmacodynamics
  • Identification of biomarkers associated with altered disease-outcome in elderly patients. 
  • Development of geriatric assessment tools to distinguish between elderly cancer patients who will and who will not benefit from treatment.
  • Performance of clinical trials assessing treatment benefits in older cancer patients.
  • Performance of clinical trials particularly addressing treatment benefits and limitations in older cancer patients with comorbidity.
  • Assessment and prevention of side and late effects in older cancer patients. 
  • Development of specific upfront rehabilitation plans for older cancer patients.
  • Explore the need for specific supportive care interventions in older cancer patients.


Scientific Staff

AgeCare will include physicians, representing several specialties (oncology, hematology, surgery, gynecology, pathology, geriatric and respiratory medicine) medical physicists and nurses. Collaborations have been agreed with translational researchers, molecular biologists and clinical pharmacologists at the University of Southern Denmark. Significant national and international collaboration has been confirmed.

Existing staff
The Clinical Research Unit, Department of Oncology: 14 research nurses, 3 research secretaries, 1 data manager, 15 Ph.D. students and 5 post docs. The unit manages 50-60 clinical trials. AgeCare will furthermore include a large number of clinical and laboratory Departments, OUH as well as cancer researchers at the Department of Cancer and Inflammation Research, SDU. The total number of current PhD students in the proposed Elite Research Center exceeds 50.


Work package leaders 

Kaare Christensen MD, DMSc, Professor, Head of Research, Epidemiology Section, SDU, Consultant, Departments of Clinical Genetics, Clinical Biochemistry and Pharmacology. Director, Danish Aging Research Center and the Danish Twin Registry. Senior Research Scientist, Sanford Institute, Duke University, USA and 340+ publications.

Henrik Frederiksen MD, PhD, Consultant, Department of Haematology, OUH. 15+ years of experience in epidemiology. PhD focused on physical functioning among elderly. Main research area is clinical epidemiology of haematological malignancies. Head of the National Haematological Danish Multidisciplinary Cancer Group (DMCG).

Henrik Ditzel MD, DMSc, Head of Research, Department of Cancer and Inflammation Research, SDU, Consultant, Department of Oncology, OUH. Adjunct Professor, Scripps Research Institute, CA, USA and Director of the Bioimaging Center DAMBic at OUH/SDU. 20+ years experience in translational cancer research (80 publications).

Lars Lund MD, DMSc, Professor, Head of Research in Urology, SDU and Consultant, Department of Urology, OUH. Member of the DMCG in renal cancer. Connected to Vanderbilt University, Tennessee in 2006/7 and performing research in comorbidity and urological cancers, 120 publications.

Olfred Hansen MD, PhD, Consultant, 20+ years of experience in the treatment of lung cancer. Head of the Radiotherapy Unit,  OUH and Associate Professor at the Institute of Clinical Research, SDU.  

Carsten Brink, Medical Physicist, PhD, Associate Professor in Radiation Physics, SDU and Assistant Chief Physicist at the Laboratory of Radiation Physics, OUH. Main research area is related to extraction of toxicity and tumor response from daily imaging modalities.

Per Pfeiffer MD, PhD, Professor, 20+ years experience in clinical oncology. Research areas, clinical and translational research in GI cancer (100+ publications). Head of the Danish Colorectal Oncology Group and member of the Nordic Biomodulating Group.

Niels Abildgaard MD, DMSc, Professor of Hematology and Head of the Research Unit at the Department of Haematology. 20+ years of experience with clinical studies in hematological disease (60 publications in this field). Chairman of the Danish and of the Nordic Myeloma Study Groups.

Jørn Herrstedt MD, DMSc, Professor, Head of Research at the Department of Oncology. Past President, Multinational Association of Supportive Care in Cancer. Board member, Nordic Society of Gynecologic Oncology. Twenty-five years experience in oncology (100+ publications).

Lars Erik Matzen MD, Head, Department of Geriatric Medicine and of the Geriatric Research Unit.     Well-established international research collaboration in Geriatric Medicine. Author or co-author of 40 peer-reviewed publications in geriatric medicine.

Niels Christian Hvidt ThD, Associate Professor, born 1969, is a Danish theologian and humanistic health researcher, trained in Copenhagen and Rome, who since 2006 has worked as an associate professor at the Institute of Public Health at University of Southern Denmark, presently at the Research Unit of General Practice. Hvidt was professor for Spiritual Care (50%) at Ludwig Maximilian University and External Research Fellow at Freiburg Institute for Advanced Studies (FRIAS). Hvidt’s researcher areas include Spirituality and Health, Spiritual Care and Patient Perspectives (100+ publications). Hvidt serves as initiator and advisor of various research networks and knowledge centers and is considered as the initiator of research in spirituality and health as a new strategic research field in Denmark.

Karin B. Dieperink, RN, MCN, PhD. Post doc at Department of Oncology, Academy of Geriatric Cancer Research (AgeCare), and Danish Knowledge Centre of Rehabilitation and Palliative Care (REHPA). Research interest is within nursing, rehabilitation, palliation and supportive care for cancer patients and their families. The research area is concerning cancer patients’ side effects and late adverse effects after treatment, quality of life and coping with the life situation and rehabilitation for prevention or reducing late adverse effects, furthermore, uncovering the impact of disease on family health and intervention with family nursing. Initiator of the Danish Research Network for Cancer Nurses.


Danish collaborative partners

Odense University Hospital (OUH)

Clinical Oncology
Jørgen Johansen Consultant, MD, PhD
Jesper Grau Eriksen Consultant, MD, PhD
Trine Lembrecht Jørgensen MD, PhD

Martin Bak Head of Department, Pathology, MD
Doris Schledermann Consultant, MD
Anne Marie Bak Jylling, Consultant, MD
Niels Marcussen Professor, MD, DMSci
Bjarne Winther Kristensen, Professor MD, PhD
Michael Boe Møller Consultant, MD, DMSci

Niels Quist Professor, MD, DMSci, Abdominal Surgery
Michael Bau Mortensen, Professor, MD, PhD, Abdominal Surgery
Gunnar Baatrup Professor MD, DMSci, Abdominal Surgery
Jens Ahm Sørensen, Consultant PhD, Plastic Surgery
Katrine Søe, Consultant MD, Plastic Surgery
Peter Licht, Professor, MD, PhD, Thoracic Surgery
Christian Godballe, Professor, MD, PhD, Head and Neck Surgery.

Pernille Hermann Consultant MD, PhD, Endocrinology
Hanne Vestergaard Head of Department, Hematology, MD, PhD
Thomas Stauffer Larsen Consultant, MD, PhD, Hematology.

Nursing and Rehabilitation
Karin Dieperink RN, MSc, PhD, Oncology
Hanne Kaa Kristensen Research Therapist, Rehabilitation.

University of Southern Denmark (SDU)
Kim Brøsen Professor, MD, DMSci, Clinical Pharmacology
Martin Røssel Larsen Professor, MSc, PhD, Faculty of Natural Sciences
Dorte Gilså Hansen MD, PhD, Head National Center for Research in Cancer Rehabilitation
Axel Skytthe PhD, Senior Data Analyst, the Danish Twin Registry/Institute of Public Health
Birte Østergaard RN, MSc, PhD, Research Unit of Nursing
Rikke Leth-Larsen Associate Professor, PhD, Cancer and Inflammation Research
Morten Gjerstorff Associate Professor, PhD, Cancer and Inflammation Research.

National collaborators
Cai Grau Professor MD, DMSci, Clinical Oncology, Aarhus University Hospital
Christoffer Johansen Professor MD, DMSci, Danish Cancer Society
Hans Storm MD, Director, Danish Cancer Society
Gerda Engholm, Senior Statistician, Danish Cancer Society
Nils Brünner Professor MD, DMSci, Faculty of Health/Medical Sciences University of Copenhagen
Bente A. Esbensen RN, PhD, Research Unit, Nursing and Health Science, Glostrup University Hospital
Dorte L. Nielsen Professor MD, PhD, DMSci, Clinical Oncology, Herlev Hospital
Finn Rønholt Head of the Department of Geriatric Medicine, MD, PhD, MPA, Herlev Hospital
Tove Lindhardt Senior Researcher, RN, MSc, Dr.Med.Sci, Department of Geriatric Medicine, Herlev Hospital
Julia S. Johansen, Professor, MD, Dr.Med.Sci, Clinical Oncology, Herlev Hospital
Nessn H Azawi MD, Consultant, Urology, Roskilde Hospital.


International high-level researchers

Lorelei Mucci, Associate Professor of Epidemiology, Harvard School of Public Health, Co-leader Cancer Epidemiology Program, Dana Farber Cancer Center, Boston, USA.
Jaakko Kaprio PhD, Professor, Department of Mental Health, National Institute for Health and Welfare and Professor of Genetic Epidemiology, University of Helsinki, Finland.

Jun Wang, Professor of Genomics and Biostatistics, Head of Beijing Genome Institute, China.

Peter E Clark MD,BA, Ass. Prof. Urologic Surgery, Vanderbilt University, Nashville, USA.
Milad Hanna MD, Consultant, Imperial Trust Hospital, London, UK.

Søren M. Bentzen, PhD, DSc, Professor of Human Oncology and Leader of the Imaging and  Radiation Science Program of the Carbone Comprehensive Cancer Center at the University of Wisconsin School of Medicine and Public Health, Wisconsin, USA.
David Ian Thwaites, Professor of Medical Physics, University of Sydney, Australia.

Matti Aapro MD, Head of Oncology Center, Clinic de Genolier, Geneva, Switzerland.
Eric Pujade-Lauraine, Professor in Oncology, PhD, Head of the Medical Oncology Department, Hôpital Hôtel-Dieu, Paris, France.
Halfdan Sørbye MD, PhD, Professor in Oncology, Haukeland University, Bergen, and
Consultant, Department of Oncology Haukeland University Hospital, Bergen, Norway.
Anders Waage MD, Dr.Med.Sci, Consultant/Professor, St. Olavs University Hospital, Norway.

Tahir Masud MD, Professor and Consultant Physician in General and Geriatric Medicine,
City Hospital NHS Trust, Nottingham, UK.
Arti Hurria MD, Associate Professor, City of Hope National Medical Center, CA, USA.            

Sarah Darby Professor of Medical Statistics, University of Oxford, UK.
Eduardo Bruera Professor, MD, Chair of the Department of Palliative Care and Rehabilitation
Medicine, MD Anderson Cancer Center, Houston, USA. 
Romy Mahrer-Imhof RN, Dr Phil, Professor Zürich University, Winterthur, Switzerland.
Marcia van Rieper, RN, Professor, PhD, University of North Carolina, Chapel Hill, USA.
Elisabeth Coyne, RN, Senior Lecturer, PhD, Logan Campus Griffith University, Australia.


Advisory board

Professor Riccardo Audisio, UK.

Professor Mario Dicato, Luxembourg

Professor Dorothy Keefe, Australia

Professor Philip Poortmans, The Netherlands

Professor Daniel F Hayes, USA



Work packages  

WP 1 Epidemiology
This WP will include five major research lines. 1) Age-trajectory of mortality and cancer. 2) Comorbidity in elderly patients with lymphoid malignancies. 3) Hereditability of various cancer forms with a special focus on the age-dependency of the genetics influence. 4) Prenatal hormonal influence on late-life cancer forms and 5) Interaction between cancer risk and longevity.

WP 2 Biomarkers
Identification of biological alterations associated with elderly patients, including differences in cancer stem cell biology. Identification of biomarkers associated with altered disease-outcome in patients with increased age, using a panel of global analysis including proteomics, next-generation sequencing, gene array and cellular and small animal bioimaging.

WP 3  Surgery
Five surgical specialities will focus on new treatment modalities and outcomes. Five areas of research related to cancer in the elderly: 1) Minimal invasive surgery, fast track. 2) Robot surgery in different cancer forms. 3) Cryo-therapy for different tumours and the use of this modality in the palliative setting. 4) Imaging in elderly patients. 5) Preserving of kidney function.

WP 4 Radiotherapy
A number of trials will investigate 1) Risk of recurrence following curative intended radiotherapy in younger versus elderly cancer patients. 2) Radiotherapy-induced side effects in  elderly cancer patients with one or more comorbid conditions. 3) The use of image-guided radiotherapy (IGRT) in elderly cancer patients who receive radiotherapy with a curative intent.   

WP 5  Medical cancer treatment
A number of phase I and II trials comprising different disease groups (lung, GI cancer, gynecologic, urologic, hematologic, breast and head and neck cancer) will be designed specifically for elderly cancer patients. These will investigate 1) Dose response of chemotherapy in elderly cancer patients. 2) Tolerability. 3) Outcome in elderly cancer patients based on subgroups of regional and national registries. 4) Pharmacokinetics and pharmacogenetics.

WP 6 Supportive Care - focusing comorbidity
This WP will use comprehensive geriatric assessment (CGA) and address comorbidity focusing 1) Mapping of comorbidity in elderly cancer patients in the  Region of Southern Denmark. 2) Preoperative CGA and interventions if needed to decrease postoperative complications and mortality. 3) Pre-chemotherapeutic CGA and interventions if needed to improve outcome of first line treatment in elderly cancer patients. 4) Pre-chemotherapeutic CGA and the ability to predict outcomes in elderly cancer patients with recurrent disease.

WP 7  Supportive Care – focusing cancer disease-related complications and treatment-induced adverse effects
Identification of late adverse effects of particular relevance to older cancer patients, e.g. bone complications. A possible relationship between side effects and pharmacokinetics and pharmacogenetics will be investigated. Rehabilitation will be another focus area. A PhD study on rehabilitation and intervention will be completed late 2013 and subsequent studies will focus on group interventions to strengthen patients' self-management and self-efficacy.

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Overview of work  packages*  
WP WP subject WP leader Numbers of
Number of
post docs
Number of


Kaare Christensen, Henrik Frederiksen

2 1 10

Biology and molecular biomarkers

Henrik Ditzel

2 2 12


Lars Lund

2 1 12

Radiation therapy

Olfred Hansen, Carsten Brink

2 3 15

Medical treatment

Per Pfeiffer, Niels Abildgaard

3 2 18

Supportive care I

Jørn Herrstedt, Lars Erik Matzen

2 1 8

Supportive care II

Niels Chritian Hvidt, Karin Dieperink

3 1 10
Total     16 11 85

*All figures indicate the expected outcome 2014-2018.

Ongoing AgeCare studies
PhD study: Importance of geriatric assessment in prediction of efficacy and tolerability of oncological therapy in older patients with gastrointestinal cancer.
Substudy: Randomised Nordic multicenter study – NORDIC 9
Substudy: Prediction of efficacy and toxicitiy of oncological therapy for older patients included in NORDIC 9.
Substudy: Older cancer patients’ attitude to chemotherapy.
AgeCare contact: Per Pfeiffer, Department of Oncology Odense University Hospital 
PhD study: Impact of CGA on QoL, overall survival and the need for admission in patients diagnosed with T1-2N0M0 NSCLC treated with SBRT – a single center randomized pilot study.
Substudy: A comparison of stereotactic body radiation therapy versus no treatment in medical inoperable patients with localized NSCLC T1-2N0M0
Substudy: A comparison of medical inoperable patients diagnosed with localized NSCLC treated with SBRT and patients with COPD without any cancer diagnosis
Substudy: A comparison of medical inoperable patients diagnosed with localized NSCLC treated with SBRT and patients with COPD without any cancer diagnosis
AgeCare contact: Olfred Hansen, Department of Oncology, Odense University Hospital.
PhD study: Significance of geriatric and biological assessment for optimal treatment of older cancer patients.
Substudy: Comorbidity among older gynecological cancer patients from the Region of Southern Denmark 2007-2011.
Substudy: Significance of oncologic treatment decision based on comprehensive geriatric assessment for optimal treatment of older gynecological and urological cancer patients.
Substudy: Biological assessment of older gynecological cancer patients with recurrent disease.
AgeCare contact: Jørn Herrstedt, Department of Oncology, Odense University Hospital
PhD study: Cardiotoxicity after radiotherapy for early breast cancer.
Substudy: Risk of pacemaker implantation subsequent to radiotherapy for early-stage breast cancer in Denmark 1982-2005.
Substudy: Risk of ischemic heart disease in women after radiotherapy for breast cancer .
Substudy: Incidence of heart disease in women treated with radiotherapy for breast cancer in Denmark 1977-2005.
Substudy: Risk of valvular heart disease in women after radiotherapy for breast cancer.
AgeCare contact: Marianne Ewertz, Department of Oncology, Odense University Hospital
PhD study: Treatment of breast cancer and risk of osteoporosis
Substudy: Treatment of breast cancer and risk of osteoporosis assessed by dual energy X-ray absorptiometry (DXA) and Xtreme-CT.
Substudy: Cross-sectional study assessing the risk of osteoporosis in patients with early-stage breast cancer, who received chemotherapy in 2009-2012.
AgeCare contact: Marianne Ewertz, Department of Oncology, Odense University Hospital
Study: Dose calculation based on cone beam CT images
AgeCare contact: Carsten Brink, Department of Oncology, Odense University Hospital
PhD study: Pre-natal hormonal influence on late life cancer
Substudy: Risk of sex-specific cancers in opposite-sex and same-sex twins in Denmark and Sweden.
AgeCare contact: Kaare Christensen, University of Southern Denmark
PhD study: The role of cancer in familial clustering of longevity
Substudy: Cancer and longevity - is there a tradeoff? A study of co-occurrence in Danish twin pairs born 1900-1918
Substudy: Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data
Substudy: Cancer and aging: epidemiological and methodological challenges
Substudy: The health of spouses marrying into longevity-enriched families
Substudy: Cancer incidence in spouses to offspring from longevity-enriched families
AgeCare contact: Kaare Christensen, University of Southern Denmark
Study: Mortality of elderly patients with comorbidity and hematological malignancies
AgeCare contact: Henrik Frederiksen, Department of Hematology, Odense University Hospital
Study: Heritability of different cancer forms
AgeCare contact: Kaare Christensen, University of Southern Denmark
Study: Molecular analysis of cellular senescence
AgeCare contact: Morten Gjerstorff, University of Southern Denmark
Study: Circulating tumor miRNA and DNA in early detection and follow-up of early stage breast cancer
AgeCare contact: Henrik Ditzel, Odense University Hospital, University of Southern Denmark
Study: Molecular analysis of endocrine resistance in younger versus elderly postmenopausal breast cancer patients
AgeCare contact: Henrik Ditzel, Odense University Hospital, University of Southern Denmark
Study: Laparoscopic nephrectomy as outpatient in elderly patients
AgeCare contact: Lars Lund, Department of Urology, Odense University Hospital
Study: Outcome after laparoscopic nephrectomy versus hand assisted laparoscopic nephrectomy as outpatient
AgeCare contact: Lars Lund, Department of Urology, Odense University Hospital
Study: Liquid biopsy in elderly patients with small renal masses
AgeCare contact: Lars Lund, Department of Urology, Odense University Hospital
Study: Liquid biopsy in elderly patients with prostate cancer
AgeCare contact: Lars Lund, Department of Urology, Odense University Hospital
Study: Prediction of lung density changes after radiotherapy by cone beam computed tomography response markers and pre-treatment factors for non-small cell lung cancer patients
AgeCare contact: Carsten Brink, Department of Oncology, Odense University Hospital
Study: Automatic Planning of Head and Neck Treatment Plans
AgeCare contact: Carsten Brink, Department of Oncology, Odense University Hospital
Study: Stereotactic radiotherapy to patients with local non-small cell lung cancer - comorbidity, efficacy and toxicity of treatment
AgeCare contact: Olfred Hansen, Department of Oncology, Odense University Hospital.
Study: Dose Calculation based on Cone Beam CT images
AgeCare contact: Carsten Brink, Department of Oncology, Odense University Hospital
Study: Analysis of PET images acquired before treatment to validate a possible association between tumor texture and tumor control after radiotherapy of non-small cell lung cancer
AgeCare contact: Carsten Brink, Department of Oncology, Odense University Hospital
Study: Head and Neck Cancer and Esophageal cancer – weight loss, - prevention of tube feeding: Nutritional support, dietary counselling: New formulas of oral nutrition with higher lipid content
AgeCare contact: Jørgen Johansen, Department of Oncology, Odense University Hospital
Study: Head and Neck Cancer: Normal tissue function
AgeCare contact: Jørgen Johansen, Department of Oncology, Odense University Hospital
Study: Head and Neck Cancer: Elderly and fragile patients - alternative RT regimen
AgeCare contact: Jesper Eriksen, Department of Oncology, Odense University Hospital
Study: Exploration of the causes for registered improved survival of elderly multiple myeloma patients in Denmark (2009-2014 vs. 2005-2008)
AgeCare contact: Niels Abildgaard, Department of Hematology, Odense University Hospital
Study: Exploration of the survival of elderly patients with acute myeloid leukaemia treated with intensive chemotherapy and allogeneic bone marrow transplantation
AgeCare contact: Niels Abildgaard, Department of Hematology, Odense University Hospital
Study: DALIAH: Randomized Phase 3 trial: Danish study on low-dose interferon alpha vs. hydroxyurea in chronic myeloproliferative neoplasms. Analysis of efficacy, tolerability and Quality of Life in elderly patients treated with interferon alpha
AgeCare contact: Thomas Stauffer Larsen, Department of Hematology, Odense University Hospital
Study: NMSG 21/13: Randomised Phase 2 trial: Ixazomib-Thalidomide-low dose Dexamethasone induction followed by maintenance therapy with Ixazomib or placebo in elderly multiple myeloma patients.
AgeCare contact: Niels Abildgaard, Department of Hematology, Odense University Hospital
Study: Impact of cytogenetics and functional imaging findings on the treatment efficacy in elderly myeloma patients treated with non-intensive chemotherapy and novel agents (part of PhD project, Brian Østergaard, MD).
AgeCare contact: Niels Abildgaard, Department of Hematology, Odense University Hospital
Study: EMMY: Early initiated individualized training in newly diagnosed multiple myeloma patients; effects on physical function, physical activity, quality of life, pain, and bone disease. Analysis of impact in elderly patients (part of PhD project, Rikke Faebo Larsen, cand. Scient. San.)
AgeCare contact: Niels Abildgaard, Department of Hematology, Odense University Hospital
Study: Quality of Life in elderly Danish Multiple Myeloma patients; impact of new therapeutics (part of PhD project, Lene Kongsgaard Nielsen, MD)
AgeCare contact: Niels Abildgaard, Department of Hematology, Odense University Hospital
Study: Long term effects after multidisciplinary rehabilitation. A three year follow up study after RCT in prostate cancer patients
AgeCare contact: Karin Dieperink, Department of Oncology, Odense University Hospital
Study: ProCaRe - Prehabilitation and early Rehabilitation in Prostate Cancer Patients – a randomised study
AgeCare contact: Karin Dieperink, Department of Oncology and Danish Knowledge Centre for Rehabilitation and Palliative Care (REHPA), Odense University Hospital
Study: Family functioning and perceived supportive care from nurses during oncologic treatment in Denmark and Australia
AgeCare contact: Karin Dieperink, Department of Oncology, Odense University Hospital